The effects of field rates of selected insecticides on the predatory mite, Phytoseiulus persimilis Athias-Henriot (Acari: Phytoseiidae), were evaluated in laboratory bioassays. In topical treatments with lufenuron, novaluron, pyrifluquinazon, and sulfoxaflor, 80–92% of P. persimilis adult females survived 168 h after exposure. Females exposed to these four insecticides produced 83–97% as many eggs as did the females in the controls, and eclosion of eggs was not affected. Moreover, the percentage of eggs that hatched and larval survival following direct exposure to these four insecticides were not seriously reduced. Immature P. persimilis survived on leaf discs with the residues of lufenuron, novaluron, pyrifluquinazon, and sulfoxaflor, with 86–94% reaching adulthood. Emamectin benzoate, lepimectin, and spirotetramat were highly toxic to P. persimilis adult females and larvae. Based on these results, lufenuron, novaluron, pyrifluquinazon, and sulfoxaflor are promising candidates for use in integrated pest management programs where P. persimilis is a natural enemy.