Renal adenocarcinoma was diagnosed in three Cape coral snakes (Aspidelaps lubricus lubricus) by histopathologic examination. A hereditary basis was suspected, because all affected snakes were genetically related. Presentations included caudal coelomic swelling as well as anorexia, regurgitation, and constipation. Moderate amounts of urate tophi throughout the kidneys were noted in all three animals. Nephrectomy appeared to prolong life if the disease was caught early and the remaining kidney was functional.