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1 April 2009 Intracytoplasmic Morphological Abnormalities in Human Oocytes
Junko Otsuki
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Abstract

In human oocytes, many types of abnormal phenotypes have been observed both within the cytoplasm and outside of the cytoplasm. The morphological evaluation of oocytes and its impact on embryo quality has been controversial. However, abnormal oocyte phenotypes can be directly influenced by the follicular environment, ovarian function and the effects of ovarian stimulation used in assisted reproductive technology. This review focuses on four critical intracytoplasmic anomalies; fluid-filled vacuoles, smooth endoplasmic reticulum clusters (sERC), refractile bodies / lipofuscin bodies and centrally located cytoplasmic granularity (CLCG). The fine structures, morphological and immunochemical characteristics and the possible mechanism giving rise to each phenotype are discussed.

Junko Otsuki "Intracytoplasmic Morphological Abnormalities in Human Oocytes," Journal of Mammalian Ova Research 26(1), 26-31, (1 April 2009). https://doi.org/10.1274/jmor.26.26
Received: 28 February 2009; Accepted: 1 March 2009; Published: 1 April 2009
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KEYWORDS
Centrally located cytoplasmic granularity
Intracytoplasmic oocyte dysmorphism
Lipofuscin / Refractile body
Smooth endoplasmic reticulum cluster
Vacuole
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