Translator Disclaimer
1 October 2009 Immune System Cooperatively Supports Endocrine System-Primed Embryo Implantation
Hiroshi Fujiwara, Atsushi Ideta, Yoshihiko Araki, Yumi Takao, Yukiyasu Sato, Noboru Tsunoda, Yoshito Aoyagi, Ikuo Konishi
Author Affiliations +
Abstract

Attachment to endometrial epithelium is an essential process for human embryos. Although it is widely accepted that this process is largely regulated by the endocrine system, the precise molecular mechanism(s) remains unclear. Recent evidence suggests that immune cells actively contribute to the establishment of embryo implantation. In accordance with this, we found that peripheral blood immune cells positively affect the differentiation of maternal endometrium to facilitate embryo implantation during early pregnancy. From these findings, we propose a novel concept that circulating immune cells are important regulators of embryo implantation. Lately, implantation failure in patients treated with in vitro fertilization and embryo transfer has received increasing attention. Based on our hypothesis, we have successfully developed a new therapy for implantation failure using autologous peripheral blood immune cells. These findings suggest that supportive mechanisms via the immune system facilitate embryo implantation and will be useful in the field of assisted reproductive technology.

Hiroshi Fujiwara, Atsushi Ideta, Yoshihiko Araki, Yumi Takao, Yukiyasu Sato, Noboru Tsunoda, Yoshito Aoyagi, and Ikuo Konishi "Immune System Cooperatively Supports Endocrine System-Primed Embryo Implantation," Journal of Mammalian Ova Research 26(3), 122-128, (1 October 2009). https://doi.org/10.1274/jmor.26.122
Received: 5 March 2009; Accepted: 1 June 2009; Published: 1 October 2009
JOURNAL ARTICLE
7 PAGES

This article is only available to subscribers.
It is not available for individual sale.
+ SAVE TO MY LIBRARY

Share
SHARE
KEYWORDS
embryo implantation
immune system
maternal recognition
PBMC
zona pellucida
RIGHTS & PERMISSIONS
Get copyright permission
Back to Top