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1 October 2013 Azoospermia Related Genes and the Detection Kit for Y Chromosome Micro Deletion
Eitetsu Koh, Masashi Iijima, Mikio Namiki
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Abstract

Azoospermia is caused by abnormality in the various genes involved in spermatogenesis. However, the crucial genes for spermatogenesis have not yet been identified. Recently, targeted knockout and transgenic mice have been generated and considerable knowledge has been accumulated about their phenotype patterns, and a wide variety of genes are known to be associated with sperm formation. First, we review the meiotic and post-meiotic phases and genes expressed during spermatogenesis. Many genes corresponding to various clinical features of azoospermia exist, and we also review azoospermia related genes from clinical aspects. The AZF (azoospermia factor) regions on the Y chromosome long arm are thought to show a major correlation with spermatogenesis. From the genomic point of view, their deletion due to intrachromosomal recombimation is reviewed as a constitutional feature of the Y chromosome. Moreover, we explain how to use a detection kit for the Y chromosome micro deletion which we developed.

Eitetsu Koh, Masashi Iijima, and Mikio Namiki "Azoospermia Related Genes and the Detection Kit for Y Chromosome Micro Deletion," Journal of Mammalian Ova Research 30(4), 135-144, (1 October 2013). https://doi.org/10.1274/jmor.30.135
Published: 1 October 2013
JOURNAL ARTICLE
10 PAGES

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KEYWORDS
AZF
azoospermia
Homologous recombination
spermatogenesis
Y CHROMOSOME
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