How to translate text using browser tools
1 January 2008 A New Ivermectin Formulation Topically Kills Permethrin-Resistant Human Head Lice (Anoplura: Pediculidae)
Joseph P. Strycharz, Kyong Sup Yoon, J. Marshall Clark
Author Affiliations +

This study examines the effectiveness of a new ivermectin formulation for the topical treatment of the human head louse, Pediculus humanus capitis De Geer (Anoplura: Pediculidae). Permethrin-resistant lice originally obtained from south Florida and maintained on an in vitro rearing system were 100% susceptible to ivermectin formulations by using a semiclinical hair tuft bioassay. The formulation was 100% effective at killing lice using 1, 0.5, and 0.25% ivermectin concentrations after 10-min exposures. As judged by the lethal time (LT)50 and LT95 values, 0.5% formulated ivermectin was 3.8 and 3.2 times faster at killing lice, respectively, than 0.5% nonformulated ivermectin, indicating that the formulation may facilitate the penetration of ivermectin into the louse. The hair tuft-based bioassay in conjunction with the in vitro rearing system provides a standardized method to assess the comparative efficacy of pediculicide formulations in a reproducible format that mimics the exposure scenario that occurs on the human scalp.

Joseph P. Strycharz, Kyong Sup Yoon, and J. Marshall Clark "A New Ivermectin Formulation Topically Kills Permethrin-Resistant Human Head Lice (Anoplura: Pediculidae)," Journal of Medical Entomology 45(1), 75-81, (1 January 2008).[75:ANIFTK]2.0.CO;2
Received: 7 May 2007; Accepted: 31 August 2007; Published: 1 January 2008

This article is only available to subscribers.
It is not available for individual sale.

human head louse
in vitro rearing system
ivermectin formulation
Pediculus humanus capitis
Get copyright permission
Back to Top