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1 May 2009 Genes Conferring Resistance to Organophosphorus Insecticides in Culex pipiens (Diptera: Culicidae) From Tunisia
Raja Ben Cheikh, Claire Berticat, Arnaud Berthomieu, Nicole Pasteur, Hassen Ben Cheikh, Myléne Weill
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Abstract

In Tunisia, the mosquito Culex pipiens shows various organophosphate resistance alleles at Ester and ace-1 loci. The characterization and the distribution pattern of these alleles were studied among 20 populations sampled from north to center of Tunisia. At the Ester locus, Ester4, Ester5, and EsterB12 were present. A new esterase characterized by the same electrophoretic migration as esterase Al was identified: A13, encoded by EsterA13 allele. At the ace-1 locus, the presence of the ace-1R, ace-1D, and F290V mutated alleles was also detected. A large heterogeneity in allelic frequencies at Ester and ace-1 loci was observed among samples, with a high significant genotypic differentiation considering both loci (Fst = 0.077, P <10-5), depicting variations of insecticide treatment intensity between areas. A comparison between populations collected in 1996 and 2005 showed an absence of significant resistance evolution. However, the high frequencies of resistance alleles in 2005 populations suggested that the selection pressures are still important in Tunisia. Strategies for resistance management are discussed in the context of the current knowledge of the Tunisian situation.

© 2009 Entomological Society of America
Raja Ben Cheikh, Claire Berticat, Arnaud Berthomieu, Nicole Pasteur, Hassen Ben Cheikh, and Myléne Weill "Genes Conferring Resistance to Organophosphorus Insecticides in Culex pipiens (Diptera: Culicidae) From Tunisia," Journal of Medical Entomology 46(3), 523-530, (1 May 2009). https://doi.org/10.1603/033.046.0317
Received: 1 April 2008; Accepted: 1 November 2008; Published: 1 May 2009
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