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1 November 2011 Altered Response to DEET Repellent After Infection of Aedes aegypti (Diptera: Culicidae) with Sindbis Virus
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To determine whether a Sindbis virus (family Togaviridae, genus Alphavirus, SINV) infection in Aedes aegypti (L.) (Diptera: Culicidae) affected its response to the repellent DEET, we orally exposed Ae. aegypti to an artificial bloodmeal containing SINV or diluent and then allowed to feed on a 10% sucrose suspension containing 3% DEET. When tested seven or more days after the initial bloodmeal, although none of the diluent-exposed mosquitoes fed on the DEET-sucrose suspension, at least 60% of the SINV-exposed mosquitoes fed on the suspension. When legs from the SINV-exposed mosquitoes were tested to determine dissemination status, 89% of those that fed on the DEET-sucrose suspension contained virus. In contrast, only 34% of the nonfeeders had a disseminated infection. When offered a choice between sucrose with or without DEET, a significantly higher percentage of the SINV-exposed mosquitoes than the control mosquitoes fed on the sucrose containing 3% DEET. Together, these results indicate that mosquitoes with a disseminated SINV infection may be less responsive to DEET than uninfected mosquitoes. Therefore, repellent use may be less effective in deterring infected mosquitoes from biting than previously believed.

© 2011 Entomological Society of America
Whitney A. Qualls, Jonathan F. Day, Rui-De Xue, and Doria F. Bowers "Altered Response to DEET Repellent After Infection of Aedes aegypti (Diptera: Culicidae) with Sindbis Virus," Journal of Medical Entomology 48(6), 1226-1230, (1 November 2011).
Received: 24 June 2010; Accepted: 1 July 2011; Published: 1 November 2011

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