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11 September 2020 Cross Resistance in S-Methoprene-Resistant Culex quinquefasciatus (Diptera: Culicidae)
Tianyun Su, Jennifer Thieme, Robert Cummings, Min-Lee Cheng, Michelle Q. Brown
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The juvenile hormone analog S-methoprene is the only synthetic biopesticide that is registered with the United States Environmental Protection Agency to control arthropods of economic importance in public health, livestock, pets, urban, and stored products. The high activity, relative target specificity, and benign environmental profile of S-methoprene have been well documented. While the risk of resistance in mosquitoes to S-methoprene is generally low, there is a lack of information regarding cross resistance in S-methoprene-resistant mosquitoes to other pesticides. In this paper, a population of the southern house mosquito Culex quinquefasciatus Say from southern California acquired low levels of resistance to S-methoprene in the field, where the resistance ratios ranged 7.0- to 8.8-fold as compared with a laboratory reference colony. After 30 generations of laboratory selections by S-methoprene when resistance was elevated to 57.4- to 168.3-fold relative to an unselected population, various levels of cross resistance to other commonly used pesticides were revealed in the selected population. Cross resistance to the microbial mosquito larvicide Lysinibacillus sphaericus (Meyer & Neide) (Bacillales: Bacillaceae) was the most profound, amounting to 77.50- to 220.50-fold. The mechanism and potential management tactics toward cross resistance are discussed to preserve the unique value of this synthetic biopesticide.

© The Author(s) 2020. Published by Oxford University Press on behalf of Entomological Society of America. All rights reserved. For permissions, please e-mail:
Tianyun Su, Jennifer Thieme, Robert Cummings, Min-Lee Cheng, and Michelle Q. Brown "Cross Resistance in S-Methoprene-Resistant Culex quinquefasciatus (Diptera: Culicidae)," Journal of Medical Entomology 58(1), 398-402, (11 September 2020).
Received: 10 July 2020; Accepted: 27 July 2020; Published: 11 September 2020

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cross resistance
Culex quinquefasciatus
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