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20 October 2023 Cache Valley virus: an emerging arbovirus of public and veterinary health importance
Holly R. Hughes, Joan L. Kenney, Amanda E. Calvert
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Cache Valley virus (CVV) is a mosquito-borne virus in the genus Orthobunyavirus (Bunyavirales: Peribunyaviri dae) that has been identified as a teratogen in ruminants causing fetal death and severe malformations during epizootics in the U.S. CVV has recently emerged as a viral pathogen causing severe disease in humans. Despite its emergence as a public health and agricultural concern, CVV has yet to be significantly studied by the scientific community. Limited information exists on CVV's geographic distribution, ecological cycle, seroprevalence in humans and animals, and spectrum of disease, including its potential as a human teratogen. Here, we present what is known of CVV's virology, ecology, and clinical disease in ruminants and humans. We discuss the current diagnostic techniques available and highlight gaps in our current knowledge and considerations for future research.

Holly R. Hughes, Joan L. Kenney, and Amanda E. Calvert "Cache Valley virus: an emerging arbovirus of public and veterinary health importance," Journal of Medical Entomology 60(6), 1230-1241, (20 October 2023).
Received: 8 March 2023; Accepted: 2 May 2023; Published: 20 October 2023

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