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24 August 2023 Histamine excretion in common indoor and hematophagous arthropods
Simona Principato, Alvaro Romero, Chow-Yang Lee, Kathleen Campbell, Dong-Hwan Choe, Coby Schal, Zachary DeVries
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Histamine is a biogenic amine that regulates multiple physiological functions in diverse organisms, specifically playing a central role in the mammalian immune response. The common bed bug, Cimex lectularius L. (Hemiptera: Cimicidae), excretes histamine in large amounts in its feces as a component of its aggregation pheromone, which contaminates homes. The potential health risks associated with the presence of indoor histamine are unclear, but to predict future exposure risks, it is critical that we understand if other arthropods excrete histamine in any discernible phylogenetic pattern. In the present study, we evaluated histamine excretion by various arthropods; specifically those commonly found in large numbers indoors, other hematophagous species, and other species in the order Hemiptera. To evaluate arthropods for histamine excretion, rearing containers for each arthropod were swabbed and/or the harborage substrates were collected. Samples were then analyzed for the presence of histamine using gas chromatography–mass spectrometry. For those arthropods where histamine was present above the method detection limit, total histamine excretion was quantified over a period of 2 wk. Our results indicate that histamine excretion is limited to hematophagous hemipterans (bed bugs, bat bugs, tropical bed bugs, and kissing bugs), suggesting that indoor histamine contamination in the United States can be primarily linked to bed bugs.

Simona Principato, Alvaro Romero, Chow-Yang Lee, Kathleen Campbell, Dong-Hwan Choe, Coby Schal, and Zachary DeVries "Histamine excretion in common indoor and hematophagous arthropods," Journal of Medical Entomology 60(6), 1269-1277, (24 August 2023).
Received: 25 April 2023; Accepted: 27 July 2023; Published: 24 August 2023

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bed bug
indoor environment
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