A SMALL HEAT SHOCK PROTEIN OF OSTERTAGIA OSTERTAGI: STAGE-SPECIFIC EXPRESSION, HEAT INDUCIBILITY, AND PROTECTION TRIAL

Isabel Vercauteren; Veerle De Maere; Jozef Vercruysse; Mieke Stevens; Kris Gevaert; Edwin Claerebout

doi:10.1645/GE-871R.1

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1 December 2006 A SMALL HEAT SHOCK PROTEIN OF OSTERTAGIA OSTERTAGI: STAGE-SPECIFIC EXPRESSION, HEAT INDUCIBILITY, AND PROTECTION TRIAL

Isabel Vercauteren, Veerle De Maere, Jozef Vercruysse, Mieke Stevens, Kris Gevaert, Edwin Claerebout

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J. of Parasitology, 92(6):1244-1250 (2006). https://doi.org/10.1645/GE-871R.1

Abstract

In this study, we isolated and analyzed a small heat shock protein (HSP) of Ostertagia ostertagi (Oo-HSP18). Oo-hsp18 is encoded by a single-copy gene and the full-length cDNA represents an 18-kDa protein. The expression of Oo-hsp18 is highly stage specific and restricted to the adult stage. The protein is synthesized in a tissue-specific manner and localized in the body muscle layer. The levels of Oo-hsp18 mRNAs are sharply induced by heat shock but not by other stressors such as levamisole and H₂O₂. A vaccination trial with recombinant Oo-HSP18 failed to protect calves against a challenge infection.

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Isabel Vercauteren, Veerle De Maere, Jozef Vercruysse, Mieke Stevens, Kris Gevaert, and Edwin Claerebout "A SMALL HEAT SHOCK PROTEIN OF OSTERTAGIA OSTERTAGI: STAGE-SPECIFIC EXPRESSION, HEAT INDUCIBILITY, AND PROTECTION TRIAL," Journal of Parasitology 92(6), 1244-1250, (1 December 2006). https://doi.org/10.1645/GE-871R.1

Received: 20 February 2006; Accepted: 1 May 2006; Published: 1 December 2006

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