Metronidazole Induces Gametocytogenesis In Gregarine Associations Maintained In Vitro

Kate Trout; Richard E. Clopton

doi:10.1645/GE-3020.1

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Kate Trout,¹ Richard E. Cloptonhttps://orcid.org/0000-0002-3741-7788^1,*

¹Department of Natural Science, Peru State College, Peru, Nebraska 68421. e-mail: rclopton@peru

^**To whom correspondence should be addressed.

Abstract

Gametocytogenesis was induced in mature associations of Protomagalhaensia wolfi and Protomagalhaensia blaberae maintained in vitro by inclusion of metronidazole in the culture medium. The response was neither strictly dosage dependent nor uniform across gregarine species. We hypothesize that metronidazole induces gregarine gametocytogenesis by disrupting PUF2 proteins responsible for the translational control of sexual development and gametocytogenesis in apicomplexans.

American Society of Parasitologists

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Kate Trout and Richard E. Clopton "Metronidazole Induces Gametocytogenesis In Gregarine Associations Maintained In Vitro," Journal of Parasitology 98(3), 666-668, (1 June 2012). https://doi.org/10.1645/GE-3020.1

Received: 24 October 2011; Accepted: 1 January 2012; Published: 1 June 2012

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