A primary hepatic carcinoma with a neuroendocrine pattern was detected in an adult female California sea lion (Zalophus californianus) found dead on Granito Island in the Gulf of California (Mexico) in January 1996. At necropsy, several light yellow nodules of different sizes were observed on the entire surface of the liver and spleen. Microscopic examination of these nodules using routine haematoxylin-eosin stain, revealed cubic, polyhedral and pleomorphic cells with three to four bizarre mitotic figures per field (40×). An immunohisto-chemistry test revealed a positive reaction of indirect immunoperoxide to cytokeratin (CK2). This is the first known case of a primary hepatic carcinoma in free-ranging California sea lions from Mexican waters.
How to translate text using browser tools
1 July 1999
Hepatic Carcinoma with Spleen Metastasis in a California Sea Lion from the Gulf of California
Karina A. Acevedo-Whitehouse,
Fernando Constantino-Casas,
David Aurioles-Gamboa,
Hector A. Rodríguez-Martínez,
Carlos R. Godínez-Reyes

Journal of Wildlife Diseases
Vol. 35 • No. 3
July 1999
Vol. 35 • No. 3
July 1999
California sea lion
case report
hepatic carcinoma
immunohistochemistry
neoplasm
pinnipeds
Zalophus californianus