Survival Patterns in White-tailed and Mule Deer after Oral Inoculation with a Standardized, Conspecific Prion Dose

Michael W. Miller; Lisa L. Wolfe; Tracey M. Sirochman; Michael A. Sirochman; Jean E. Jewell; Elizabeth S. Williams

doi:10.7589/0090-3558-48.2.526

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Michael W. Miller,^1,* Lisa L. Wolfe,¹ Tracey M. Sirochman,¹ Michael A. Sirochman,¹ Jean E. Jewell,² Elizabeth S. Williams^2,3

¹1 Colorado Division of Wildlife, Wildlife Research Center, 317 West Prospect Road, Fort Collins, Col
²2 Wyoming State Veterinary Laboratory, Department of Veterinary Sciences, University of Wyoming, 117
³3 Deceased 29 December 2004

^* Corresponding author (email: mike.miller@state.co.us)

Abstract

We orally inoculated white-tailed deer (Odocoileus virginianus) and mule deer (Odocoileus hemionus) with a standardized, conspecific prion dose and collected biologic samples throughout the disease course. Mule deer (PRNP genotype 225SS) and PRNP genotype 96GG white-tailed deer succumbed along similar trajectories, but 96GS- and 96SS-genotype individuals tended to survive longer.

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Michael W. Miller, Lisa L. Wolfe, Tracey M. Sirochman, Michael A. Sirochman, Jean E. Jewell, and Elizabeth S. Williams "Survival Patterns in White-tailed and Mule Deer after Oral Inoculation with a Standardized, Conspecific Prion Dose," Journal of Wildlife Diseases 48(2), 526-529, (1 April 2012). https://doi.org/10.7589/0090-3558-48.2.526

Received: 8 September 2011; Accepted: 1 November 2011; Published: 1 April 2012

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