A fatal diffuse granulomatous pneumonia and focal necrotizing hepatitis were found at necropsy of three 6-month old caimans. Centers of the widely disseminated, discrete lesions in the lungs had a branching fungus with septate hyphae, chlamydospores, and elliptical and cigar-shaped conidia. On culture the fungal organism was identified as Cephalosporium sp. Characteristics of the genus are discussed.