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1 January 2010 Response to Vaccination with a Commercial Inactivated Rabies Vaccine in a Captive Colony of Brazilian Free-Tailed Bats (Tadarida brasiliensis)
Amy S. Turmelle, Louise C. Allen, Barbara A. Schmidt-French, Felix R. Jackson, Thomas H. Kunz, Gary F. McCracken, Charles E. Rupprecht
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Abstract

A captive colony of Brazilian free-tailed bats (Tadarida brasiliensis) was vaccinated with a commercial monovalent inactivated rabies virus (RABV) vaccine (RABVAC 1). Baseline rabies virus neutralizing antibodies (VNA) and the response to vaccination were measured in 50 bats. Rabies VNA was detected in the plasma of 64% (27/42) of bats that had been vaccinated 1 yr prior, but only 19% (8/42) had levels considered adequate. Rabies VNA was detected in the plasma of 63% (5/8) of bats with no record of previous vaccination, suggesting natural RABV exposure before captivity. All bats demonstrated a VNA response by 10 days postvaccination, and baseline titer significantly predicted humoral response to vaccination. No adverse reactions to vaccination or clinical signs of RABV infection were observed in the bats during a 6-mo observation period. Annual vaccination may maintain immunity against RABV infection in captive colonies of bats.

Amy S. Turmelle, Louise C. Allen, Barbara A. Schmidt-French, Felix R. Jackson, Thomas H. Kunz, Gary F. McCracken, and Charles E. Rupprecht "Response to Vaccination with a Commercial Inactivated Rabies Vaccine in a Captive Colony of Brazilian Free-Tailed Bats (Tadarida brasiliensis)," Journal of Zoo and Wildlife Medicine 41(1), 140-143, (1 January 2010). https://doi.org/10.1638/2008-0161.1
Received: 10 September 2008; Published: 1 January 2010
JOURNAL ARTICLE
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KEYWORDS
Bat
rabies virus
Tadarida brasiliensis
vaccination
virus neutralizing antibodies
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