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1 March 2016 CLINICAL INFECTION OF TWO CAPTIVE ASIAN ELEPHANTS (ELEPHAS MAXIMUS) WITH ELEPHANT ENDOTHELIOTROPIC HERPESVIRUS 1B
Angela Fuery, Jie Tan, RongSheng Peng, Joseph P. Flanagan, Maryanne E. Tocidlowski, Lauren L. Howard, Paul D. Ling
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Abstract

The ability of prior infection from one elephant endotheliotropic herpesvirus (EEHV) type to protect against clinical or lethal infection from others remains an important question. This report describes viremia and subsequent shedding of EEHV1B in two juvenile 4-yr-old Asian elephants within 3 wk or 2 mo following significant infections caused by the rarely seen EEHV4. High levels of EEHV1B shedding were detected in the first elephant prior to emergence of infection and viremia in the second animal. The EEHV1B virus associated with both infections was identical to the strain causing infection in two herd mates previously. High EEHV viremia correlated with leukopenia and thrombocytopenia, which was followed by leukocytosis and thrombocytosis when clinical signs started to resolve. The observations from these cases should be beneficial for helping other institutions monitor and treat elephants infected with EEHV1, the most common virus associated with lethal hemorrhagic disease.

Copyright 2016 by American Association of Zoo Veterinarians
Angela Fuery, Jie Tan, RongSheng Peng, Joseph P. Flanagan, Maryanne E. Tocidlowski, Lauren L. Howard, and Paul D. Ling "CLINICAL INFECTION OF TWO CAPTIVE ASIAN ELEPHANTS (ELEPHAS MAXIMUS) WITH ELEPHANT ENDOTHELIOTROPIC HERPESVIRUS 1B," Journal of Zoo and Wildlife Medicine 47(1), 319-324, (1 March 2016). https://doi.org/10.1638/2015-0074.1
Received: 2 April 2015; Published: 1 March 2016
JOURNAL ARTICLE
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KEYWORDS
Asian elephant
EEHV1B
Elephas maximus
famciclovir
qPCR
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