The objective of this study was to investigate the pharmacokinetics of a long-acting fentanyl solution in helmeted guineafowl (Numida meleagris) after transdermal administration. Twenty-one guineafowl received a single administration of 5 mg/kg of fentanyl transdermal solution. No adverse effects on behavior were appreciated. Plasma fentanyl concentrations were determined by liquid chromatography–mass spectrometry analysis of protein-precipitated samples. Mean maximum plasma concentration was 228.8 ng/ml at 4 hr. The mean plasma terminal half-life was 33.2 hr. At 168 hr the mean plasma concentration was 1.3 ng/ml. A single topical dose of 5 mg/kg appears to be safe for use in this species and maintained plasma concentrations above those reported to be analgesic in dogs for at least 7 days.
How to translate text using browser tools
1 June 2016
PHARMACOKINETIC EVALUATION OF A LONG-ACTING FENTANYL SOLUTION AFTER TRANSDERMAL ADMINISTRATION IN HELMETED GUINEAFOWL (NUMIDA MELEAGRIS)
Lynnette Waugh,
Heather Knych,
Gretchen Cole,
Jennifer D'Agostino
ACCESS THE FULL ARTICLE
analgesia
Avian
fentanyl solution
guineafowl
Numida meleagris
Recuvyra™