Tumors are infrequently reported in skunks, with only a few case reports published in the literature. Chylothorax associated with mediastinal lymphoma was diagnosed in a captive 7-yr-old male striped skunk (Mephitis mephitis). The animal presented with anorexia and apathy. Supportive care and prednisolone improved the animal's clinical status for 2 wk preceding its death. Histopathology supported the clinical findings, and the tumor was classified as a mediastinal non–Hodgkin lymphoma, stage 2b, which has not been documented in the literature.
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