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1 June 2017 KETAMINE-MEDETOMIDINE AND KETAMINE-MEDETOMIDINE-MIDAZOLAM ANESTHESIA IN CAPTIVE CHEETAHS (ACINONYX JUBATUS)—COMPARISON OF BLOOD PRESSURE AND KIDNEY BLOOD FLOW
Julia Stagegaard, Arne Hørlyck, Helle B. Hydeskov, Mads F. Bertelsen
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Abstract

Six clinically healthy captive cheetahs (Acinonyx jubatus) were anesthetized twice using two different drug combinations to investigate if blood pressure and kidney blood flow are affected by medetomidine dosage. Protocol KM (2.0 mg/kg ketamine and 0.05 mg/kg medetomidine) was compared with protocol KMM (2.0 mg/kg ketamine, 0.02 mg/kg medetomidine, and 0.1 mg/kg midazolam). Heart rate (HR), respiratory rate (RR), body temperature, end-tidal carbon dioxide pressure (ETCO2), and anesthetic depth were monitored every 10 min. Noninvasive mean (MAP), systolic (SAP), and diastolic (DAP) arterial blood pressure were measured, and Duplex Doppler ultrasonography was performed on the kidneys. The mean arterial resistive index (RI) was determined and the pulse pressure index (PPI) was calculated, as indicators for kidney blood flow. There were no significant differences in induction and recovery times. MAP was significantly higher with KM than KMM at 35 min, and in both protocols decreased significantly after atipamezole administration. DAP was significantly higher at 25 and 35 min in animals anesthetized with KM; it also decreased significantly with both protocols after atipamezole administration. The PPI was significantly lower throughout the procedure with KM, and with both protocols increased significantly after atipamezole administration. Both the higher blood pressure and the reduced PPI with KM were likely a direct effect of the higher medetomidine dosage, and these findings indicate that lower medetomidine dosages might reduce hypertension and lead to a better PPI in cheetah immobilization.

Copyright 2017 by American Association of Zoo Veterinarians
Julia Stagegaard, Arne Hørlyck, Helle B. Hydeskov, and Mads F. Bertelsen "KETAMINE-MEDETOMIDINE AND KETAMINE-MEDETOMIDINE-MIDAZOLAM ANESTHESIA IN CAPTIVE CHEETAHS (ACINONYX JUBATUS)—COMPARISON OF BLOOD PRESSURE AND KIDNEY BLOOD FLOW," Journal of Zoo and Wildlife Medicine 48(2), 363-370, (1 June 2017). https://doi.org/10.1638/2016-0128R.1
Accepted: 1 February 2017; Published: 1 June 2017
JOURNAL ARTICLE
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KEYWORDS
blood pressure
cheetah
ketamine
kidney
medetomidine
midazolam.
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