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1 June 2017 EPITHELIOTROPIC INTESTINAL T-CELL LYMPHOMA IN A HARBOR SEAL (PHOCA VITULINA)
Sara Malberg, Henrike Alma Gregersen, Manfred Henrich, Christiane Herden
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Abstract

A 14-yr- old, male harbor seal (Phoca vitulina) presented with depression, anorexia, and weight loss. Clinical examination revealed no specific abnormalities. Diagnostic imaging displayed an enlarged mass in the dorso-cranial abdomen. The animal was euthanized due to progressive worsening of symptoms. Grossly, severe emaciation and a massive enlargement of one mesenteric lymph node were found. Microscopically, a neoplastic round cell population with morphologic characteristics of mature lymphocytes infiltrated the mesenteric lymph node as well as the jejunal mucosa and exhibited a marked invasion of the mucosal epithelial layer. Immunohistochemically, the majority of cells expressed CD3, but not CD79α, indicating a T-cell origin of the tumor cells. Microscopic as well as immunohistochemical findings enabled the diagnosis of an epitheliotropic intestinal T-cell lymphoma, a neoplasm that has yet not been described in a harbor seal.

Copyright 2017 by American Association of Zoo Veterinarians
Sara Malberg, Henrike Alma Gregersen, Manfred Henrich, and Christiane Herden "EPITHELIOTROPIC INTESTINAL T-CELL LYMPHOMA IN A HARBOR SEAL (PHOCA VITULINA)," Journal of Zoo and Wildlife Medicine 48(2), 568-572, (1 June 2017). https://doi.org/10.1638/20160221R.1
Received: 30 January 2017; Published: 1 June 2017
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KEYWORDS
Epitheliotropic lymphoma
harbor seal (Phoca vitulina)
intestinal T-cell lymphoma
intestinal tract
neoplasia
pinnipeds
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