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1 December 2017 SUCCESSFUL TREATMENT OF A CLINICAL ELEPHANT ENDOTHELIOTROPIC HERPESVIRUS INFECTION: THE DYNAMICS OF VIRAL LOAD, GENOTYPE ANALYSIS, AND TREATMENT WITH ACYCLOVIR
Supaphen Sripiboon, Taweepoke Angkawanish, Khajohnpat Boonprasert, Petthisak Sombutputorn, Warangkhana Langkaphin, William Ditcham, Kristin Warren
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Abstract

This article describes the treatment of clinical elephant endotheliotropic herpesvirus (EEHV) infection in a male Asian elephant (Elephas maximus; approximately 3 yr old), the dynamics of viral load during the active infection, and genetic analysis of the virus. Treatment included injectable acyclovir (12 mg/kg iv, bid), antibiotic, vitamin, and fluids. Quantitative polymerase chain reaction was used to measure the viral levels in blood, which decreased continuously after initiation of intravenous acyclovir. Low levels of virus were detected in the blood for 2 wk, and the virus was undetectable after 1 mo. No complication was observed during the treatment period. This case report suggests that acyclovir, given parenterally, could potentially enhance survival of clinical EEHV-infected individuals.

Copyright 2017 by American Association of Zoo Veterinarians
Supaphen Sripiboon, Taweepoke Angkawanish, Khajohnpat Boonprasert, Petthisak Sombutputorn, Warangkhana Langkaphin, William Ditcham, and Kristin Warren "SUCCESSFUL TREATMENT OF A CLINICAL ELEPHANT ENDOTHELIOTROPIC HERPESVIRUS INFECTION: THE DYNAMICS OF VIRAL LOAD, GENOTYPE ANALYSIS, AND TREATMENT WITH ACYCLOVIR," Journal of Zoo and Wildlife Medicine 48(4), 1254-1259, (1 December 2017). https://doi.org/10.1638/2016-0141R1.1
Received: 8 July 2017; Published: 1 December 2017
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