The fixation of fractures in wild animals has been a great challenge for veterinarians, because they will inevitably face a unique anatomical characteristic with scarce studies or reports published. Fracture fixation should promote adequate stability and early return to limb function, taking into account biomechanical characteristics of the bones, body weight, and natural habits of wildlife. Three bone fractures from two giant anteaters (Myrmecophaga tridactyla) referred at the veterinary teaching hospital on different occasions were treated by a double plating technique. The two free-ranging anteaters incurred their injuries when struck by an automobile. The first anteater (Ant 1) had a complete oblique fracture of the proximal third of the right femur and a complete comminuted fracture of the distal third of the right tibia. Surgical stabilization was performed by double plating to stabilize the femur and tibia. The second anteater (Ant 2) had a complete transverse fracture of the mid-diaphysis of the right radius and ulna, and it was fixed with a medial plate on the radius and a caudal plate on the ulna. The patients were able to walk 24 hr after the surgical procedures. Bone consolidation was observed at 60 days postoperatively, with no complications. The biggest challenges were related to anatomical characteristics for surgical approaches and the ability to promote a fixation strong enough to support the weight and strength of the animal, allowing early return to limb function.