A juvenile intact female ornate box turtle (Terrapene ornata ornata) was referred for evaluation of right-sided appendicular swelling that was nonresponsive to antimicrobial therapy. Computed tomography (CT) revealed severe soft tissue swelling of the limbs and neck, with multiple associated tortuous gas-filled sinus tracts extending from the cutaneous surface, which contained oblong soft tissue attenuating structures. These CT findings were most consistent with migrating dipterous larvae. Surgical exploration was performed and six sarcophagid larvae (Superfamily Oestroidea) were extracted. To our knowledge, this is the first case report in veterinary medicine providing antemortem CT imaging features of cutaneous myiasis in a reptile.