A new species of Lycianthes (Dunal) Hassler (Solanaceae, Capsiceae) is described and illustrated. Lycianthes bullata C. I. Orozco, C. A. Vargas & Serralde is found at low altitudes in the Pacific region of Colombia. This species belongs to the subgenus Polymeris (Dunal) Bitter; it is a vine and exhibits stellate and stalked ferruginous hairs and unifoliate sympodia. It is related to L. ferruginea Bitter but can be distinguished from this species by the intense ferruginous color of its indument; its larger foliar lamina (6.5–19 × 5–9 cm), elliptic to ovate, with adaxial surface glossy and bullate, and abaxial surface extremely reticulate; its larger flowers (15–17 mm long); the presence of five or six stamens; and its larger fruits (16–30 mm in diam.).