Streptanthus glandulosus Hooker subsp. josephinensis Al-Shehbaz & M. Mayer (Brassicaceae) is described as new. The new combinations S. glandulosus subsp. niger (Greene) Al-Shehbaz, M. Mayer & D. W. Taylor, S. glandulosus subsp. sonomensis (Kruckeberg) M. Mayer & D. W. Taylor, and S. vimineus (Greene) Al-Shehbaz & D. W. Taylor, as well as a new status for S. glandulosus subsp. albidus (Greene) Al-Shehbaz, M. Mayer & D. W. Taylor and S. glandulous subsp. hoffmanii (Kruckeberg) M. Mayer & D. W. Taylor, are proposed. A key to the eight subspecies of S. glandulosus is presented. Mesoreanthus fallax Greene and S. sparsiflorus Rollins are reduced to synonymy of S. vimineus and S. platycarpus A. Gray, respectively. The names M. vimineus Greene and S. niger Greene are lectotypified. The IUCN status of S. glandulosus subsp. josephinensis is given as Critically Endangered (CE).