Myriocarpa Bentham (Urticaceae), a genus endemic to Central and South America, is characterized by string-like pendent pistillate inflorescences. Among Mesoamerican species, there is significant confusion over the application of names, especially M. bifurca Liebmann, M. cordifolia Liebmann, and M. heterospicata Donnell Smith. Two new species from Mesoamerica are described and illustrated: M. cubilgueitzensis A. K. Monro and M. trifurca A. K. Monro. In addition, a key to the seven species recognized for Mesoamerica and a nomenclatural review are provided. The names M. bifurca Liebmann, M. cordifolia Liebmann, and M. longipes Liebmann are lectotypified, and the name M. colipensis Liebmann is neotypified.