Polystemma mirandae Lozada-Pérez (Apocynaceae, Asclepiadoideae) is described and illustrated from Guerrero, Oaxaca, and Puebla, Mexico. This new species is distinguished by the corolla limb and lobes densely strigillose on the adaxial surface and by the corona lobes with two lateral acicular appendages. Its relation with species of the genera is discussed.
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