Scutellaria sipilensis Cuevas (Lamiaceae) is proposed as a new species from Jalisco, Mexico, which is accommodated within section Cardinales Epling or in the species group “speciosa” as defined by Paton. The species is related to S. longifolia Benth., S. glabra Leonard, S. saslayensis A. Pool, and S. rosei Fernald, from which it differs by its widely ovate leaves, trichomes of greater size, persistent bracts, and in general by its much smaller floral structures.