Englerocharis cuzcoensis Al-Shehbaz (Brassicaceae), a new species from the Peruvian department of Cuzco, is described and illustrated. It is easily distinguished from the closely related E. ancashensis Al-Shehbaz, A. Cano & Trinidad by having caducous sepals, ciliate leaf bases, 24 to 32 ovules/seeds per ovary/fruit, and long-sericeous trichomes 0.9–1.5 mm long. The novelty is readily separated from other congeners by having caducous sepals and yellow petals. A synopsis and a key distinguishing the six species of Englerocharis Muschl. are presented.