Matelea anomala Morillo, Meve & Liede (Apocynaceae, Asclepiadeae, Gonolobinae) is here described and illustrated. The new taxon, known only from a single locality in eastern central Bolivia, is characterized by very small flowers with a campanulate corolla and recurved, abaxially pubescent and not ocellate corolla lobes, an annular corona with fimbriate-crenulate margins, and a terete stipe carrying the gynostegium. The new species is recognized in Matelea Aubl. s. str., for which a generic description is provided as well as a key to the species occurring in Bolivia.