Aluminum ion complexed 5,8-di-Br-hypocrellin B is a new water-soluble perylenequinonoid derivative with enhanced absorption over hypocrellin B (HB) in the phototherapeutic window (600–900 nm). Electron paramagnetic resonance and 9,10-diphenyl-anthracene bleaching methods were used to investigate the photosensitizing activity of [Al2(5,8-di-Br-HB)Cl4]n in the presence of oxygen. Singlet oxygen, superoxide anion radical and hydroxyl radical can be generated by [Al2(5,8-di-Br-HB)Cl4]n photosensitization. Singlet oxygen (1O2) is formed via energy transfer from triplet-state [Al2(5,8-di-Br-HB)Cl4]n to ground-state molecular oxygen. 1O2 participates in the generation of a portion of superoxide anion radical (O2·−). Besides superoxide anion radical (O2·−) may originate from the electron transfer between the triplet-state [Al2(5,8-di-Br-HB)Cl4]n and the ground-state molecular oxygen. ·OH is formed through the Fenton–Haber–Weiss reaction and the decomposition of DMPO–1O2 adduct. Compared with HB [Al2(5,8-di-Br-HB)Cl4]n primarily remains and enhances the generation efficiency of superoxide anion radical and hydroxyl radical but that of singlet oxygen decreases.
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Vol. 74 • No. 2