Translator Disclaimer
1 December 2002 A Comparison of Protoporphyrin IX and Protoporphyrin IX Dimethyl Ester as a Photosensitizer in Poorly Differentiated Human Nasopharyngeal Carcinoma Cells
Author Affiliations +
Abstract

Protoporphyrin IX dimethyl ester (PME), a dimethyl esterification of protoporphyrin IX (PpIX), exhibits higher intracellular uptake into NPC/CNE2 cells, a poorly differentiated human nasopharyngeal carcinoma, than does PpIX. Phototoxicity studies reveal PME to be a more potent photosensitizer than is PpIX, at the early and late incubation time points. Correlating phototoxicity with subcellular localization indicates that PME is a more potent photosensitizer when its primary target of photodamage is mitochondria. Also, additional targeting of lysosome enhances phototoxicity.

Karen Kar Lye Yee, Khee Chee Soo, Boon Huat Bay, and Malini Olivo "A Comparison of Protoporphyrin IX and Protoporphyrin IX Dimethyl Ester as a Photosensitizer in Poorly Differentiated Human Nasopharyngeal Carcinoma Cells," Photochemistry and Photobiology 76(6), 678-682, (1 December 2002). https://doi.org/10.1562/0031-8655(2002)076<0678:ACOPIA>2.0.CO;2
Received: 8 July 2002; Accepted: 1 September 2002; Published: 1 December 2002
JOURNAL ARTICLE
5 PAGES

This article is only available to subscribers.
It is not available for individual sale.
+ SAVE TO MY LIBRARY

SHARE
ARTICLE IMPACT
RIGHTS & PERMISSIONS
Get copyright permission
Back to Top