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1 February 2003 Photodynamic Effects of Antioxidant Substituted Porphyrin Photosensitizers on Gram-positive and -negative Bacteria
Helena Ashkenazi, Yeshayahu Nitzan, Dezso Gál
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Abstract

Photodynamic treatment of the gram-negative bacteria Escherichia coli B and Acinetobacter baumannii and the gram-positive bacterium Staphylococcus aureus was performed using two newly devised and synthesized antioxidant carrier photosensitizers (antioxidant carrier sensitizers-2 [ACS-2] and antioxidant carrier sensitizers-3 [ACS-3]), which are butyl hydroxy toluene and propyl gallate substituted haematoporphyrins, respectively. It was found that ACS-2 is less reactive than other photosensitizers previously used for the same purpose, whereas ACS-3 is very effective against the multidrug-resistant bacterium A. baumannii, causing its complete eradication at a low fluence (∼7.5 J/cm) of blue light (407–420 nm) and a low concentration (10 μM). At a higher fluence (∼37.5 J/cm) complete eradication of E. coli B can be obtained under the same conditions. Furthermore, X-ray microanalysis and ultrastructural changes indicate that ACS-3, especially in the case of photodynamic treatment of A. baumannii, interferes with membrane functions and causes the inactivation of the bacterium. ACS-3 may be suggested as a specific photosensitization agent for photoinactivation of gram-negative bacteria.

Helena Ashkenazi, Yeshayahu Nitzan, and Dezso Gál "Photodynamic Effects of Antioxidant Substituted Porphyrin Photosensitizers on Gram-positive and -negative Bacteria," Photochemistry and Photobiology 77(2), 186-191, (1 February 2003). https://doi.org/10.1562/0031-8655(2003)077<0186:PEOASP>2.0.CO;2
Received: 3 July 2002; Accepted: 1 November 2002; Published: 1 February 2003
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