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1 June 2003 Increased Intensities of YOYO-1–labeled DNA Oligomers Near Silver Particles
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Abstract

DNA detection is usually performed using fluorescence probes. Using a DNA oligomer stained with the widely used dye 1,1′-[1,3-propanediylbis[(dimethylimino)-3,1-propanediyl]]bis[4-[(3-methyl-2(3H)-benzoxazolylidene)methyl]]-quinolinum tetraiodide (YOYO-1), we show that a substrate containing silver particles can lead to a greater than 10-fold increase in the fluorescence intensity. Proximity to silver particles also increases the photostability of YOYO-1–DNA. These results suggest that substrates or gels containing silver particles may be used for increased sensitivity in DNA detection.

Joseph R. Lakowicz, Joanna Malicka, and Ignacy Gryczynski "Increased Intensities of YOYO-1–labeled DNA Oligomers Near Silver Particles," Photochemistry and Photobiology 77(6), 604-607, (1 June 2003). https://doi.org/10.1562/0031-8655(2003)077<0604:IIOYDO>2.0.CO;2
Received: 30 January 2003; Accepted: 1 March 2003; Published: 1 June 2003
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