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1 July 2003 Elevated Serum Cytokine Levels in Mesothelioma Patients Who Have Undergone Pleurectomy or Extrapleural Pneumonectomy and Adjuvant Intraoperative Photodynamic Therapy
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Abstract

Patients treated on a Phase-I clinical trial of photodynamic therapy (PDT) developed a systemic capillary leak syndrome that constituted the dose-limiting toxicity. We examined serum samples from patients treated at the maximally tolerated dose level for evidence of a systemic, cytokine-mediated inflammatory response. Patients underwent pleurectomy or extrapleural pneumonectomy (EPP) followed by intraoperative PDT of the thorax using Foscan® at a dose of 0.1 mg/kg 6 days before surgery and 652 nm red light at a dose of 10 J/cm2. Levels of interferon-γ (IFN-γ), tumor necrosis factor–α (TNF-α), interleukin (IL)-1β, IL-6, IL-8, IL-10 and IL-12 were assayed before Foscan® administration; after anesthetic induction, surgical resection and light delivery; in postoperative recovery and the day after the surgery. Of the analyzed patients, eight underwent a pleurectomy and one an EPP followed by PDT. IFN-γ, TNF-α and IL-12 showed no elevation, but IL-1β, IL-6, IL-8 and IL-10 levels were elevated after surgery and PDT. IL-1β showed a statistically significant variation from baseline after surgery and IL-6, after PDT. The results suggest a systemically mediated inflammatory response resulting from thoracic surgery followed by PDT. Further investigation of specific mechanisms is warranted.

Sue S. Yom, Theresa M. Busch, Joseph S. Friedberg, E. Paul Wileyto, Deborah Smith, Eli Glatstein, and Stephen M. Hahn "Elevated Serum Cytokine Levels in Mesothelioma Patients Who Have Undergone Pleurectomy or Extrapleural Pneumonectomy and Adjuvant Intraoperative Photodynamic Therapy," Photochemistry and Photobiology 78(1), 75-81, (1 July 2003). https://doi.org/10.1562/0031-8655(2003)078<0075:ESCLIM>2.0.CO;2
Received: 20 December 2002; Accepted: 1 April 2003; Published: 1 July 2003
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