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1 August 2003 Synthesis and Photoinduced DNA Cleaving Activity of Hairpin Polyamide–Chlorobenzenesulfonyl Conjugate
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Abstract

A hairpin polyamide–chlorobenzenesulfonyl conjugate was synthesized in solution by a haloform reaction and the dicyclohexylcarbodiimide/1-hydroxybenzotriazole (DCC/HOBT) coupling reaction. Its ability to cleave DNA was investigated with supercoiled DNA (pBluescript SK), and the DNA cleaving efficiency of chlorobenzenesulfonyl group was enhanced by the hairpin polyamide under UV irradiation (365 nm).

Fei Li Tang, Gu Yuan, and Jin Wang "Synthesis and Photoinduced DNA Cleaving Activity of Hairpin Polyamide–Chlorobenzenesulfonyl Conjugate," Photochemistry and Photobiology 78(2), 175-179, (1 August 2003). https://doi.org/10.1562/0031-8655(2003)078<0175:SAPDCA>2.0.CO;2
Received: 6 November 2002; Accepted: 1 February 2003; Published: 1 August 2003
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