This study compares stem cell research policymaking by legislators and citizens in the United States. First, using exit poll results from a 2006 stem cell research initiative in Missouri, the study finds that deeply held personal values such as religious beliefs and views of abortion predominate in an individual's voting decision on this issue; second, an analysis of voting behavior by senators on the Stem Cell Research Enhancement Act of 2005 finds that senators make their voting decisions based on their personal policy preferences rather than their constituents' preferences; and third, the complexity of the Missouri citizen initiative is compared with that of the legislation in the U.S. Senate, finding that the language of the citizen initiative is more sophisticated than the language of the legislative act. These findings provide the context for a broader discussion of the role of citizens and legislators in making policy for science.