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1 March 2004 Single Low Doses of X Rays Inhibit the Development of Experimental Tumor Metastases and Trigger the Activities of NK Cells in Mice
Aneta Cheda, Jolanta Wrembel-Wargocka, Emil Lisiak, Ewa M. Nowosielska, Maria Marciniak, Marek K. Janiak
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Abstract

Cheda, A., Wrembel-Wargocka, J., Lisiak, E., Nowosielska, E. M., Marciniak, M. and Janiak, M. K. Single Low Doses of X Rays Inhibit the Development of Experimental Tumor Metastases and Trigger the Activities of NK Cells in Mice. Radiat. Res. 161, 335–340 (2004).

There is evidence indicating that low-level exposures to low- LET radiation may inhibit the development of tumors, but the mechanism of this effect is virtually unknown. In the present study, BALB/c mice were irradiated with single doses of 0.1 or 0.2 Gy X rays and injected intravenously 2 h later with syngeneic L1 sarcoma cells. Compared to the values obtained for sham-irradiated control mice, the numbers of pulmonary tumor colonies were significantly reduced in the animals exposed to either 0.1 or 0.2 Gy X rays. Concurrently, a significant stimulation of NK cell-mediated cytotoxic activity was detected in splenocyte suspensions obtained from irradiated mice compared to sham-exposed mice. Intraperitoneal injection of the NK-suppressive anti-asialo GM1antibody totally abrogated the tumor inhibitory effect of the exposures to 0.1 and 0.2 Gy X rays. These results indicate that single irradiations of mice with either 0.1 or 0.2 Gy X rays suppress the development of experimental tumor metastases primarily due to the stimulation of the cytolytic function of NK cells by radiation.

Aneta Cheda, Jolanta Wrembel-Wargocka, Emil Lisiak, Ewa M. Nowosielska, Maria Marciniak, and Marek K. Janiak "Single Low Doses of X Rays Inhibit the Development of Experimental Tumor Metastases and Trigger the Activities of NK Cells in Mice," Radiation Research 161(3), 335-340, (1 March 2004). https://doi.org/10.1667/RR3123
Received: 6 May 2003; Accepted: 1 October 2003; Published: 1 March 2004
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