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1 March 2004 Decreases in Percentages of Naïve CD4 and CD8 T Cells and Increases in Percentages of Memory CD8 T-Cell Subsets in the Peripheral Blood Lymphocyte Populations of A-Bomb Survivors
Mika Yamaoka, Yoichiro Kusunoki, Fumiyoshi Kasagi, Tomonori Hayashi, Kei Nakachi, Seishi Kyoizumi
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Abstract

Yamaoka, M., Kusunoki, Y., Kasagi, F., Hayashi, T., Nakachi, K. and Kyoizumi, S. Decreases in Percentages of Naïve CD4 and CD8 T Cells and Increases in Percentages of Memory CD8 T-Cell Subsets in the Peripheral Blood Lymphocyte Populations of A-Bomb Survivors. Radiat. Res. 161, 290–298 (2004).

Our previous studies have revealed a clear dose-dependent decrease in the percentage of naïve CD4 T cells that are phenotypically CD45RA in PBL among A-bomb survivors. However, whether there is a similar radiation effect on CD8 T cells has remained undetermined because of the unreliability of CD45 isoforms as markers of naïve and memory subsets among the CD8 T-cell population. In the present study, we used double labeling with CD45RO and CD62L for reliable identification of naïve and memory cell subsets in both CD4 and CD8 T-cell populations among 533 Hiroshima A-bomb survivors. Statistically significant dose-dependent decreases in the percentages of CD45RO/CD62L naïve cells were found in the CD8 T-cell population as well as in the CD4 T-cell population. Furthermore, the percentages of CD45RO / CD62L and CD45RO /CD62Lmemory T cells were found to increase significantly with increasing radiation dose in the CD8 T-cell population but not in the CD4 T-cell population. These results suggest that the prior A-bomb exposure has induced long-lasting deficits in both naïve CD4 and CD8 T- cell populations along with increased proportions of these particular subsets of the memory CD8 T-cell population.

Mika Yamaoka, Yoichiro Kusunoki, Fumiyoshi Kasagi, Tomonori Hayashi, Kei Nakachi, and Seishi Kyoizumi "Decreases in Percentages of Naïve CD4 and CD8 T Cells and Increases in Percentages of Memory CD8 T-Cell Subsets in the Peripheral Blood Lymphocyte Populations of A-Bomb Survivors," Radiation Research 161(3), 290-298, (1 March 2004). https://doi.org/10.1667/RR3143
Received: 3 September 2003; Accepted: 1 November 2003; Published: 1 March 2004
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