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1 June 2004 Effects of Pd-bacteriopheophorbide (TOOKAD)-Mediated Photodynamic Therapy on Canine Prostate Pretreated with Ionizing Radiation
Zheng Huang, Qun Chen, Nadira Trncic, Susan M. LaRue, Pierre-Hervé Brun, Brian C. Wilson, Howard Shapiro, Fred W. Hetzel
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Abstract

Huang, Z., Chen, Q., Trncic, N., LaRue, S. M., Brun, P., Wilson, B. C., Shapiro, H. and Hetzel, F. W. Effects of Pd-bacteriopheophorbide (TOOKAD)-Mediated Photodynamic Therapy on Canine Prostate Pretreated with Ionizing Radiation. Radiat. Res. 161, 723–731 (2004).

The aim of this study was to evaluate the effects of photodynamic therapy (PDT) using a novel palladium bacteriopherophorbide photosensitizer TOOKAD (WST09) on canine prostate that had been pretreated with ionizing radiation. To produce a physiological and anatomical environment in canine prostate similar to that in patients for whom radiotherapy has failed, canine prostates (n = 4) were exposed to ionizing radiation (54 Gy) 5 to 6 months prior to interstitial TOOKAD-mediated PDT. Light irradiation (763 nm, 50–200 J/cm at 150 mW/cm from a 1-cm cylindrical diffusing fiber) was delivered during intravenous infusion of TOOKAD at 2 mg/kg over 10 min. Interstitial measurements of tissue oxygen profile (pO2) and of local light fluence rate were also measured. The prostates were harvested for histological examination 1 week after PDT. The baseline pO2 of preirradiated prostate was in the range 10–44 mmHg. The changes in relative light fluence rate during PDT ranged from 12 to 43%. The acute lesions were characterized by hemorrhagic necrosis, clearly distinguishable from the radiotherapy-induced pre-existing fibrosis. The lesion size was correlated with light fluence and comparable to that in unirradiated prostate treated with a similar TOOKAD-PDT protocol. There was no noticeable damage to the urethra, bladder or adjacent colon. The preliminary results obtained from a small number of animals indicate that TOOKAD-PDT can effectively ablate prostate pretreated with ionizing radiation, and so it may provide an alternative modality for those prostate cancer patients for whom radiotherapy has failed.

Zheng Huang, Qun Chen, Nadira Trncic, Susan M. LaRue, Pierre-Hervé Brun, Brian C. Wilson, Howard Shapiro, and Fred W. Hetzel "Effects of Pd-bacteriopheophorbide (TOOKAD)-Mediated Photodynamic Therapy on Canine Prostate Pretreated with Ionizing Radiation," Radiation Research 161(6), 723-731, (1 June 2004). https://doi.org/10.1667/RR3186
Received: 19 September 2003; Accepted: 1 November 2003; Published: 1 June 2004
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