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1 August 2004 Two-Year Chronic Bioassay Study of Rats Exposed to a 1.6 GHz Radiofrequency Signal
Larry E. Anderson, David M. Sheen, Bary W. Wilson, Sondra L. Grumbein, Jeffery A. Creim, Lyle B. Sasser
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Abstract

Anderson, L. E., Sheen, D. M., Wilson, B. W., Grumbein, S. L., Creim, J. A. and Sasser, L. B. Two-Year Chronic Bioassay Study of Rats Exposed to a 1.6 GHz Radiofrequency Signal. Radiat. Res. 162, 201–210 (2004).

The purpose of this study was to determine whether long-term exposure to a 1.6 GHz radiofrequency (RF) field would affect the incidence of cancer in Fischer 344 rats. Thirty-six timed-pregnant rats were randomly assigned to each of three treatment groups: two groups exposed to a far-field RF Iridium signal and a third group that was sham exposed. Exposures were chosen such that the brain SAR in the fetuses was 0.16 W/kg. Whole-body far-field exposures were initiated at 19 days of gestation and continued at 2 h/day, 7 days/week for dams and pups after parturition until weaning (∼23 days old). The offspring (700) of these dams were selected, 90 males and 90 females for each near-field treatment group, with SAR levels in the brain calculated to be as follows: (1) 1.6 W/kg, (2) 0.16 W/kg and (3) near-field sham controls, with an additional 80 males and 80 females as shelf controls. Confining, head-first, near-field exposures of 2 h/day, 5 days/week were initiated when the offspring were 36 ± 1 days old and continued until the rats were 2 years old. No statistically significant differences were observed among treatment groups for number of live pups/litter, survival index, and weaning weights, nor were there differences in clinical signs or neoplastic lesions among the treatment groups. The percentages of animals surviving at the end of the near-field exposure were not different among the male groups. In females a significant decrease in survival time was observed for the cage control group.

Larry E. Anderson, David M. Sheen, Bary W. Wilson, Sondra L. Grumbein, Jeffery A. Creim, and Lyle B. Sasser "Two-Year Chronic Bioassay Study of Rats Exposed to a 1.6 GHz Radiofrequency Signal," Radiation Research 162(2), 201-210, (1 August 2004). https://doi.org/10.1667/RR3208
Received: 7 February 2003; Accepted: 1 April 2004; Published: 1 August 2004
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