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1 November 2005 A Variable-Energy Electron Microbeam: A Unique Modality for Targeted Low-LET Radiation
Marianne B. Sowa, Mark K. Murphy, John H. Miller, Joseph C. McDonald, Daniel J. Strom, Gregory A. Kimmel
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Abstract

Sowa, M. B., Murphy, M. K., Miller, J. H., McDonald, J. C., Strom, D. J. and Kimmel, G. A. A Variable-Energy Electron Microbeam: A Unique Modality for Targeted Low-LET Radiation. Radiat. Res. 164, 695–700 (2005).

We have designed and constructed a low-cost, variable-energy low-LET electron microbeam that uses energetic electrons to mimic radiation damage produced by γ and X rays. The microbeam can access lower regions of the LET spectrum, similar to conventional X-ray or 60Co γ-ray sources. The device has two operating modes, as a conventional microbeam targeting single cells or subpopulations of cells or as a pseudo broad-beam source allowing for direct comparison with conventional sources. By varying the incident electron energy, the target cells can be selectively exposed to different parts of the energetic electron tracks, including the track ends.

Marianne B. Sowa, Mark K. Murphy, John H. Miller, Joseph C. McDonald, Daniel J. Strom, and Gregory A. Kimmel "A Variable-Energy Electron Microbeam: A Unique Modality for Targeted Low-LET Radiation," Radiation Research 164(5), 695-700, (1 November 2005). https://doi.org/10.1667/RR3463.1
Received: 30 December 2003; Accepted: 1 July 2005; Published: 1 November 2005
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