BioOne.org will be down briefly for maintenance on 17 December 2024 between 18:00-22:00 Pacific Time US. We apologize for any inconvenience.
How to translate text using browser tools
1 October 2006 CHK2-Dependent Phosphorylation of BRCA1 in Hypoxia
Shannon L. Gibson, Ranjit S. Bindra, Peter M. Glazer
Author Affiliations +
Abstract

Gibson, S. L., Bindra, R. S. and Glazer, P. M. CHK2-Dependent Phosphorylation of BRCA1 in Hypoxia. Radiat. Res. 166, 646–651 (2006).

Hypoxia induces a diverse spectrum of changes in the expression and activity of numerous DNA repair factors within the tumor microenvironment. In particular, we and others have shown that hypoxia induces phosphorylation and activation of the checkpoint kinase, CHK2, in an ATM-dependent manner. One downstream target of CHK2, the BRCA1 protein, plays a critical role in both DNA repair and cell cycle checkpoint regulation in mammalian cells. Here we report that BRCA1 is specifically phosphorylated on Serine 988 in response to hypoxic stress, and phosphorylation at this site is dependent on CHK2 expression. These findings enhance our understanding of ATM-CHK2 pathway activation in hypoxia, and they identify a novel role for BRCA1 in the response to hypoxic stress.

Shannon L. Gibson, Ranjit S. Bindra, and Peter M. Glazer "CHK2-Dependent Phosphorylation of BRCA1 in Hypoxia," Radiation Research 166(4), 646-651, (1 October 2006). https://doi.org/10.1667/RR0660.1
Received: 20 April 2006; Accepted: 1 June 2006; Published: 1 October 2006
RIGHTS & PERMISSIONS
Get copyright permission
Back to Top