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1 January 2007 Analysis of Boron Distribution In Vivo for Boron Neutron Capture Therapy using Two Different Boron Compounds by Secondary Ion Mass Spectrometry
Kunio Yokoyama, Shin-Ichi Miyatake, Yoshinaga Kajimoto, Shinji Kawabata, Atsushi Doi, Toshiko Yoshida, Motonori Okabe, Mitsunori Kirihata, Koji Ono, Toshihiko Kuroiwa
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Abstract

Yokoyama, K., Miyatake, S-I., Kajimoto, Y., Kawabata, S., Doi, A., Yoshida, T., Okabe, M., Kirihata, M., Ono, K. and Kuroiwa, T. Analysis of Boron Distribution In Vivo for Boron Neutron Capture Therapy using Two Different Boron Compounds by Secondary Ion Mass Spectrometry. Radiat. Res. 167, 102–109 (2007).

The efficiency of boron neutron capture therapy (BNCT) for malignant gliomas depends on the selective and absolute accumulation of 10B atoms in tumor tissues. Only two boron compounds, BPA and BSH, currently can be used clinically. However, the detailed distributions of these compounds have not been determined. Here we used secondary ion mass spectrometry (SIMS) to determine the histological distribution of 10B atoms derived from the boron compounds BSH and BPA. C6 tumor-bearing rats were given 500 mg/kg of BPA or 100 mg/kg of BSH intraperitoneally; 2.5 h later, their brains were sectioned and subjected to SIMS. In the main tumor mass, BPA accumulated heterogeneously, while BSH accumulated homogeneously. In the peritumoral area, both BPA and BSH accumulated measurably. Interestingly, in this area, BSH accumulated distinctively in a diffuse manner even 800 μm distant from the interface between the main tumor and normal brain. In the contralateral brain, BPA accumulated measurably, while BSH did not. In conclusion, both BPA and BSH each have advantages and disadvantages. These compounds are considered to be essential as boron delivery agents independently for clinical BNCT. There is some rationale for the simultaneous use of both compounds in clinical BNCT for malignant gliomas.

Kunio Yokoyama, Shin-Ichi Miyatake, Yoshinaga Kajimoto, Shinji Kawabata, Atsushi Doi, Toshiko Yoshida, Motonori Okabe, Mitsunori Kirihata, Koji Ono, and Toshihiko Kuroiwa "Analysis of Boron Distribution In Vivo for Boron Neutron Capture Therapy using Two Different Boron Compounds by Secondary Ion Mass Spectrometry," Radiation Research 167(1), 102-109, (1 January 2007). https://doi.org/10.1667/RR0501.1
Received: 6 December 2005; Accepted: 1 July 2006; Published: 1 January 2007
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