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1 February 2007 Reduction of Background Mutations by Low-Dose X Irradiation of Drosophila Spermatocytes at a Low Dose Rate
Takao Koana, Mikie O. Okada, Keiji Ogura, Hidenobu Tsujimura, Kazuo Sakai
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Abstract

Koana, T., Okada, M. O., Ogura, K., Tsujimura, H. and Sakai, K. Reduction of Background Mutations by Low-Dose X Irradiation of Drosophila Spermatocytes at a Low Dose Rate. Radiat. Res. 167, 217–221 (2007).

A sex-linked recessive lethal mutation assay was performed in Drosophila melanogaster using immature spermatocytes and spermatogonia irradiated with X rays at a high or low dose rate. The mutation frequency in the sperm irradiated with a low dose at a low dose rate was significantly lower than that in the sham-irradiated group, whereas irradiation with a high dose resulted in a significant increase in the mutation frequency. It was obvious that the dose–response relationship was not linear, but rather was U-shaped. When mutant germ cells defective in DNA excision repair were used instead of wild-type cells, low-dose irradiation at a low dose rate did not reduce the mutation frequency. These observations suggest that error-free DNA repair functions were activated by low dose of low-dose-rate radiation and that this repaired spontaneous DNA damage rather than the X-ray-induced damage, thus producing a practical threshold.

Takao Koana, Mikie O. Okada, Keiji Ogura, Hidenobu Tsujimura, and Kazuo Sakai "Reduction of Background Mutations by Low-Dose X Irradiation of Drosophila Spermatocytes at a Low Dose Rate," Radiation Research 167(2), 217-221, (1 February 2007). https://doi.org/10.1667/RR0705.1
Received: 6 June 2006; Accepted: 1 September 2006; Published: 1 February 2007
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