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1 April 2007 DNA Core Ionization and Cell Inactivation
Arnaud Boissière, Christophe Champion, Alain Touati, Marie-Anne Hervé du Penhoat, Laure Sabatier, Aloke Chatterjee, Annie Chetioui
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Abstract

Boissière, A., Champion, C., Touati, A., Hervé du Penhoat, M. A., Sabatier, L., Chatterjee, A. and Chetioui, A. DNA Core Ionization and Cell Inactivation. Radiat. Res. 167, 493–500 (2007).

Whether inner-shell ionizations of DNA atoms, called core ionizations, are critical events for cell inactivation by ionizing radiations such as 100 keV electrons and γ rays has been investigated. The number of core ionizations in DNA atoms per gray of the two types of radiations is calculated from various Monte Carlo track simulations. The probability that a core ionization leads to cell inactivation is deduced from experimental values of the RBEs of ultrasoft X rays. The contribution to V79 cell inactivation solely due to the core ionizations in DNA is found to be 75 ± 27% for energetic electrons and γ rays. This surprisingly large contribution strongly suggests the presence of new mechanisms associated with critical lesions for cell inactivation.

Arnaud Boissière, Christophe Champion, Alain Touati, Marie-Anne Hervé du Penhoat, Laure Sabatier, Aloke Chatterjee, and Annie Chetioui "DNA Core Ionization and Cell Inactivation," Radiation Research 167(4), 493-500, (1 April 2007). https://doi.org/10.1667/RR0451.1
Received: 7 October 2005; Accepted: 1 November 2006; Published: 1 April 2007
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