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1 January 2008 Analysis of Functional Groups of Differentially Expressed Genes in the Peripheral Blood of Patients with Cervical Cancer Undergoing Concurrent Chemoradiation Treatment
Angel Chao, Tzu-Hao Wang, Yun-Shien Lee, Ji-Hong Hong, Chi-Neu Tsai, Chun-Kai Chen, Chien-Sheng Tsai, An-Shine Chao, Chyong-Huey Lai
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Abstract

Chao, A., Wang, T. H., Lee, Y. S., Hong, J. H., Tsai, C. N., Chen, C. K., Tsai, C. S., Chao, A. S. and Lai, C. H. Analysis of Functional Groups Differentially Expressed Genes in the Peripheral Blood of Patients with Cervical Cancer Undergoing Concurrent Chemoradiation Treatment. Radiat. Res. 169, 76–86 (2008).

We prospectively investigated the gene expression profiles of cervical cancer patients undergoing concurrent chemoradiation treatment. Up-regulated genes associated with anemia were analyzed. Peripheral blood of 20 patients (bulky stage IB–IVA cervical squamous cell carcinomas) undergoing concurrent chemoradiation treatment at four times was collected. Total RNA extracted by the PAXgene Blood RNA System was analyzed with microarrays and MetaCore™ functional network analyses. Fifty-three genes were significantly differentially expressed during concurrent chemoradiation treatment. Fetal and embryonic hemoglobin genes were up-regulated when patients had been severely myelosuppressed. Twenty-eight genes correlated significantly with the hemoglobin genes are involved in responses to hypoxia and oxygenation, TGF-β signaling, cell cycle suppression, G-protein signaling, and transcriptional regulation. c-Myc has the highest rank in transcriptional co-regulation. In addition, IGKV1D-13 was significantly down-regulated in patients with severe hematological toxicity. These approaches identified biological processes in peripheral blood modulated by concurrent chemoradiation treatment and subsequent anemia.

Angel Chao, Tzu-Hao Wang, Yun-Shien Lee, Ji-Hong Hong, Chi-Neu Tsai, Chun-Kai Chen, Chien-Sheng Tsai, An-Shine Chao, and Chyong-Huey Lai "Analysis of Functional Groups of Differentially Expressed Genes in the Peripheral Blood of Patients with Cervical Cancer Undergoing Concurrent Chemoradiation Treatment," Radiation Research 169(1), 76-86, (1 January 2008). https://doi.org/10.1667/RR1045.1
Received: 27 March 2007; Accepted: 1 September 2007; Published: 1 January 2008
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