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1 April 2008 Histone Deacetylase Inhibitors Protect against and Mitigate the Lethality of Total-Body Irradiation in Mice
Stephen L. Brown, Andrew Kolozsvary, Jianguo Liu, Samuel Ryu, Jae Ho Kim
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Abstract

Brown, S. L., Kolozsvary, A., Liu, J., Ryu, S. and Kim, J. H. Histone Deacetylase Inhibitors Protect against and Mitigate the Lethality of Total-Body Irradiation in Mice. Radiat. Res. 169, 474–478 (2008).

It was hypothesized that histone deacetylase (HDAC) inhibitors may increase survival after total-body irradiation (TBI) based on previous reports demonstrating that HDAC inhibitors stimulate the proliferation of bone marrow stem cells. Using the time for mice to lose 20% or more of their weight as the end point, two HDAC inhibitors, valproic acid and trichostatin-A, were found to reduce lethality in a dose-dependent manner. HDAC inhibitors were effective at reducing lethality when given either 24 h before or 1 h after TBI. The results indicate that HDAC inhibitors have potential for protecting against and mitigating radiation-induced lethality.

Stephen L. Brown, Andrew Kolozsvary, Jianguo Liu, Samuel Ryu, and Jae Ho Kim "Histone Deacetylase Inhibitors Protect against and Mitigate the Lethality of Total-Body Irradiation in Mice," Radiation Research 169(4), 474-478, (1 April 2008). https://doi.org/10.1667/RR1245.1
Received: 1 October 2007; Accepted: 1 December 2007; Published: 1 April 2008
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